Leo Q. Wan

Qun (Leo) Wan
Name: Qun (Leo) Wan
Title:Assistant Professor
Department Biomedical Engineering
School Engineering
Center Center for Biotechnology and Interdisciplinary Studies (CBIS) Center for Modeling, Simulation and Imaging in Medicine (CEMSIM)
Website:http://www.rpi.edu/~wanq
Bio Leo received both B.S. and M. Eng. degrees in Mechanical Engineering from the University of Science and Technology of China (USTC), and a PhD in Biomedical Engineering from Columbia University, where he became a post-doc on stem cells and tissue engineering. He joined the Biomedical Engineering Department at the Rensselaer Polytechnic Institute as an assistant professor in 2011.

Leo's research interests focus on studying physical biology in tissue development and tissue regeneration and developing microassays and technologies for disease diagnosis and drug screening. His research involves multidisciplinary approaches, which include aspects of tissue engineering, biomaterial, bioimaging, cell/tissue biomechanics, and micro-/nano- biotechnology.

Leo is a Pew scholar (Class 2013), and recipient of National Science Foundation Early Career Award, American Heart Association Scientist Development Grant, and the March of Dimes Basil O’Connor Starter Scholar Research Award.
Details
Education Ph.D. in Biomedical Engineering, Columbia University 2007; M.Eng. in Fluid Mechanics, University of Science and Technology of China (USTC) 2001; B.S. in Theoretical and Applied Mechanics, University of Science and Technology of China (USTC) 1998;
Scholarly Works:
  • LQ Wan*, K Ronaldson, M Guirguis, and G. Vunjak-Novakovic*, 2013. Micropatterning of Cells Reveals Chiral Morphogenesis, Stem Cell Research and Therapy, 4:24-31.
  • K Worley, A Certo, and LQ Wan*, 2013. Geometry-Force Control of Stem Cell Fate, BioNanoScience, 3(1), pp. 43-51.
  • LQ Wan, K Ronaldson, M Park, G Taylor, Y Zhang, JM Gimble, and G Vunjak-Novakovic. Micropatterned Mammalian Cells Exhibit Phenotype-Specific Left-Right Asymmetry, Proceedings of National Academy of Science, 108(30), pp. 12295-300.
  • NT Khanarian, J Jiang, LQ Wan, VC Mow, and HH Lu, 2012. A Hydrogel-Mineral Composite Scaffold for Osteochondral Interface Tissue Engineering, Tissue Engineering, 18(5-6), pp. 533-45.
  • T Zhang, LQ Wan, A Marsano, R Maidhof, and G Vunjak-Novakovic, 2012. Chitosan-Collagen Based Channeled Scaffold for Cardiac Tissue Engineering, Journal of Tissue Engineering and Regenerative Medicine, 6(9), pp.748-756.
  • LQ Wan and G Vunjak-Novakovic. Micropatterning Chiral Morphogenesis, 2011. Communicative & Integrative Biology, 4(6), pp. 748-756.
  • AF Godier-Furnémont, TP Martens, MS Koeckert, LQ Wan, JJ Parks, K Arai, G Zhang, BJ Hudson, S Homma, and G Vunjak-Novakovic, 2011. Composite Scaffold Provides A Cell Delivery Platform For Cardiovascular Repair, Proceedings of National Academy of Science, 108(19), pp. 7974-9.
  • N Tandon, A Marsano, R Maidhof, LQ Wan, H Park, and G Vunjak-Novakovic, 2011. Optimization of Electrical Stimulation Parameters for Cardiac Tissue Engineering, Journal of Tissue Engineering & Regenerative Medicine, 5(6), pp.115-25.
  • LQ Wan, J Jiang, DE Arnold, XE Guo, VC Mow, and HH Lu, 2011. Matrix Deposition Modulates Viscoelastic Shear Properties of Hydrogel-Based Engineered Cartilage Tissue, Tissue Engineering Part A, 17(7-8), pp.1111-22.
  • LQ Wan, SM Kang, G Eng, WL Grayson, XL Lu, B Huo, J Gimble, XE Guo, VC Mow, and G Vunjak-Novakovic, 2010. Geometric Control of Adult Human Stem Cell Morphology and Differentiation, Integrative Biology, 2(7-8), pp. 346-53.
  • A Marsano, R Maidhof, LQ Wan, Y Wang, J Gao, N Tandon, and G Vunjak-Novakovic, 2010. Scaffold Stiffness Affects the Contractile Function of Three-Dimensional Engineered Cardiac Constructs, Biotechnology Progress, 26(5), pp.1382-90.
  • XL Lu, LQ Wan, XE Guo, and VC Mow, 2010. A Linearized Formulation of Triphasic Mixture Theory for Articular Cartilage, and Its Application to Indentation Analysis, Journal of Biomechanics, 43(4), pp. 673-9.
  • LQ Wan, XE Guo, and VC Mow, 2010. A Triphasic Orthotropic Laminate Model for Cartilage Curling Behavior: Fixed Charge Density vs. Mechanical Properties Inhomogeneity, Journal of Biomechanical Engineering, 132(2): 4504.
  • WL Grayson, M Fröhlich, K Yeager, S Bhumiratana, C Canizzarro, LQ Wan, E Chan, X Liu, XE Guo, and G Vunjak-Novakovic, 2010. Engineering Anatomically-Shaped Human Mandibular Bone Grafts, Proceedings of National Academy of Science, 107(8), pp. 3299-304.
  • DO Freytes, LQ Wan, and G Vunjak-Novakovic, 2009. Geometry and Force Control of Cell Function, Journal of Cellular Biochemistry, 108(5), pp. 1047-58.
  • TP Martens, AFG Godier, JP Parks, LQ Wan, MS Koeckert, J Ifkovits, JA Burdick, W Sherman, and G Vunjak-Novakovic, 2009. Catheter-Based Delivery and In Situ Polymerization of Cell-Hydrogel Suspensions, Cell Transplantation, 18(3), pp. 297-304.
  • LQ Wan and VC Mow, 2008. Cellular and Molecular Biomechanics: the Articular Cartilage Paradigm — A Review, Journal of Medical Biomechanics, 23(1), pp. 1-18.
  • M Fröhlich, WL Grayson, LQ Wan, D Marolt, M Drobnic, and G Vunjak-Novakovic, 2008. Tissue Engineered Bone Grafts: Biological Requirements, Tissue Culture and Clinical Relevance, Current Stem Cell Research & Therapy, 2008, 3 (4), pp. 254-264.
  • LQ Wan, J Jiang, DE Arnold, XE Guo, HH Lu, and VC Mow, 2008. Calcium Concentration Effects on the Mechanical and Biochemical Properties of Chondrocyte-Alginate Constructs, Cellular and Molecular Bioengineering, 1(1), pp. 93-102.
  • LQ Wan, C Miller, XE Guo, and VC Mow, 2004. Fixed Electrical Charges and Mobile Ions Affect the Measurable Mechano-Electrochemical Properties of Charged-Hydrated Biological Tissues: The Articular Cartilage Paradigm, Mechanics & Chemistry of Biosystems, 1(1), pp. 81-99
Recognitions:
  • Rising Star Award, 2013 Annual BMES-CMBE Conference, Waimea, HI
  • Young Investigator Award, Frontiers in Bioengineering Workshop, Atlanta, GA, 2013
  • National Science Foundation Early Career Award, 2013
  • American Heart Association Scientist Development Grant, 2013
  • Pew Scholars in Biomedical Sciences, 2013
  • the March of Dimes Basil O’Connor Starter Scholar Research Award, 2014