Biomedical Engineering

Angel Garcia
Name: Angel Garcia
Title:Professor of Physics and Senior Constellation Professor in Biocomputation and Bioinformatics
Department Biomedical Engineering Chemical and Biological Engineering Physics, Applied Physics & Astronomy
School Science
Website:http://rpi.edu/dept/phys/faculty/profiles/garcia.html
Bio García received a Ph.D. in Theoretical Physics from Cornell University . He is a fellow of the American Physical Society and a member of the Biophysical Society, The Protein Society, the AAAS, and the American Chemical Society. He received the Edward Bouchard prize of the American Physical Society in 2006.
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Education Ph.D., Theoretical Physics, Cornell University. M.S., Physics, University of Puerto Rico, Rio Piedras B.S., Physics (Magna cum Laude), University of Puerto Rico, Rio Piedras
Scholarly Works:
  • S. Gnanakaran, R. Nussinovand A. E. García, “Atomic level description of amyloid beta dimer formation” J Amer. Chem Soc. (Communications) 128: 2158-2159 (2006) A.E. Garcia and J. N. Onuchic, “Folding a protein in the computer: Reality or hope?” (Commentary) STRUCTURE 13: 497-498 (2005)
James A. Cooper
Name: James A. Cooper
Title:Assistant Professor
Department Biomedical Engineering
School Engineering
Center Center for Biotechnology and Interdisciplinary Studies (CBIS)
Bio Dr. Cooper received his Ph.D. degree from Drexel University and was a National Research Council (NRC) Post-Doctoral Associate at the National Institutes of Standards and Technology (NIST). At NIST, he specialized in the area of tissue engineering that included investigations with bioreactors, bioimaging and 3-D scaffold fabrication. In 2007, he became an inaugural 2006 Hartwell Foundation Fellow at the University of Pennsylvania’s Tissue Microfabrication Laboratory (TML) in the Department of Bioengineering. At the TML, he specialized in studies investigating the interaction between cells and their microenvironments. He used novel microfabrication tools to monitor the interactions of mesenchymal stem cells in order to better understand how the cells function under static conditions as they commit to chondrogenic and osteogenic lineages in the same cellular mass for the development of an osteochondral implant.

Dr. Cooper reviews for several journals including the Journal of Biomedical Materials Research, Acta Biomaterialia and Journal of Polymer Research.

Dr. Cooper’s interests and the general areas of research of his laboratory include the multidisciplinary areas of Biomaterials, Cell and Tissue Engineering, Orthopedics, Stem Cell Biology, Materials Fabrication, Bioimaging, Bioreactors and Biosensors.
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Education Ph.D. Biomedical Science (Drexel University, 2002) M.S. Materials (Pennsylvania State University, 1993) B.A. Chemistry (Lincoln University, 1989)
Scholarly Works:
  • Engineering controllable anisotropy in electrospun biodegradable nanofibrous scaffolds for musculoskeletal tissue engineering (2007)
  • Osteogenic differentiation of dura mater stem cells cultured in vitro on three-dimensional porous scaffolds of poly(
  • Perfusion Flow Bioreactor for 3-D In Situ Imaging: Investigating Cell-Biomaterial Interactions (2007)
  • Systematic Investigation of Porogen Size and Content on Scaffold Morphometric Parameters and Properties (2007)
  • A Systematic Study on Fabrication and Characterization of Electrospun Poly(alpha-hydroxy ester) based Nanofibrous Scaffolds (2006)
  • Biomimetic Tissue-Engineered Anterior Cruciate Ligament Replacement (2007)
  • Tissue Engineering of Bone and Ligament A 15-year Perspective (2006)
  • Encapsulated Chondrocyte Response to Pulsatile Flow Bioreactor (2007)
  • Tissue Engineering Scaffolds Based on Photocured Dimethacrylate Polymers for In Vitro Optical Imaging (2006)
David T. Corr
Name: David T. Corr
Department Biomedical Engineering
School Engineering
Center Center for Biotechnology and Interdisciplinary Studies (CBIS)
Bio David T. Corr received his B.S. and M.S. degrees from the Department of Engineering Mechanics & Astronautics, University of Wisconsin. After working as a consultant at NASA's Jet Propulsion Laboratory, under the funding of the Universities Space Research Association, Dr. Corr returned to the University of Wisconsin to earn his M.S. degree from the Department of Biomedical Engineering and his Ph.D. from the Department of Mechanical Engineering. Following a one-year Postdoctoral Research Associateship in the Medical School at the University of Wisconsin, Dr. Corr spent two years as a Postdoctoral Fellow in muscle physiology and modeling at the Human Performance Laboratory of the University of Calgary, and two years as the Ernst & Young Fellow in Joint Injury and Arthritis Research, at the McCaig Centre, University of Calgary.

Dr. Corr's research addresses the experimental evaluation and theoretical modeling of biological soft tissues, such as skeletal muscle, skin, and ligament, and their healing response following injury.

He is a member of numerous professional societies including the Orthopaedic Research Society and the Wound Healing Society, and has held memberships in the American College of Sports Medicine, American Society of Biomechanics, and the Canadian Society for Biomechanics. Dr. Corr serves as a reviewer for several journals in the areas of biomedical engineering, biomechanics, and soft tissue mechanics.

Dr. Corr was most recently a postdoctoral fellow at the University of Calgary's McCaig Centre for Joint Injury & Arthritis Research, where he specialized in orthopedic soft tissue biomechanics; investigating the development of osteoarthritis, as well as wound healing in skin, ligament and skeletal muscle. An outstanding young researcher with broad-based knowledge and interests, Dr. Corr brings to the department a strong background in theoretical and applied mechanics, coupled with research at the whole tissue level.
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Education Ph.D. Mechanical Engineering (University of Wisconsin, 2001)
M.S. Biomedical Engineering, M.S. Engineering Mechanics & Astronautics (University of Wisconsin, 1994)
B.S. Engineering Mechanics & Astronautics (University of Wisconsin, 1992)
Steven Cramer
Name: Steven Cramer
Title:William Weightman Walker Professor
Department Biomedical Engineering Chemical and Biological Engineering
School Engineering
Website:https://afsws.rpi.edu/AFS/dept/chem-eng/WWW/faculty/cramer/
Bio Professor Steven Cramer is one of the recognized leaders in chromatographic bioprocessing worldwide. For the past twenty three years, Professor Cramer and his students have combined elegant theoretical models and rigorous experimentation to make dramatic advances in several areas of preparative protein chromatography. He serves as a consultant and/or member of the scientific board for several biotechnology and separations companies. In addition, Professor Cramer is known worldwide for his expertise in separations in general. He is the Editor-in-Chief of the International journal Separations, Science and Technology. Professor Cramer was the awarded the prestigious Alan S. Michaels Award for the Recovery of Biological Products (ACS Division of Biochemical Technology). He was also awarded Rensselaer’s School of Engineering Research Excellence Award, a Presidential Young Investigator award from the National Science Foundation, the Early Career Award from Rensselaer Polytechnic Institute as well as several teaching awards. Professor Cramer was elected a fellow of the American Institute for Medical and Biological Engineering. He has also chaired several prestigious meetings including the International HIC/RPC Bioseparations Conference, the ACS Recovery of Biological Products Meeting and the Gordon Conference on Reactive Polymers. He is also the U.S. coordinator of the NSF sponsored Eastern Mediterranean Chemical Engineering Conference Series. Prof. Cramer has published over 140 papers in peer-reviewed journals and has 9 patents. Importantly, he has produced over 33 Ph.D. students who have gone on to leadership positions in the biotechnology industry and academia.
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Education B.S. 1978 Brown University Ph.D. 1986 Yale University
Guohao Dai
Name: Guohao Dai
Title:Assistant Professor
Department Biomedical Engineering
Center Center for Biotechnology and Interdisciplinary Studies (CBIS)
Bio Professional Background:
Dr. Dai graduated from Beijing University, China with B.S. in Mechanical Engineering and M.S. in Biomechanics, where he performed research on cardiovascular system modeling and the dynamic coupling of left ventricle and systemic arteries. After that, he came to Massachusetts Institute of Technology and subsequently joined the Harvard-MIT Division of Health Science’s Medical Engineering and Medical Physics program. During his Ph.D. studies, he did research in Fluid Mechanics Laboratory at MIT and Vascular Surgery Research Laboratory at Massachusetts General Hospital. There, he developed a biomechanical model to analyze venous blood flow and tissue mechanics in the lower leg, and optimized the design of external pneumatic compression (EPC) device for better deep vein thrombosis (DVT) prophylaxis. Then, he completed Post-doctoral training in Dr. Michael Gimbrone’s laboratory (Center for Excellence in Vascular Biology) at Harvard Medical School. His research focuses on the influence of biomechanical force on endothelial phenotypic modulation and its role on pathogenesis of atherosclerosis. He has developed an in vitro system to recreate arterial shear stress waveforms acquired from atherosclerosis-susceptible and -resistant regions of human vasculature, and studied endothelial functions under these conditions. Using this system, combined with genome-wide transcriptional profiling strategies, his work has revealed distinct global gene expression patterns and some of the underlying molecular mechanisms that are responsible for the disease-prone and –protected phenotypes of vascular endothelium.

Dr. Dai’s education and research experiences concentrate in the field of cardiovascular biomechanics and vascular biology. He is a member of Biomedical Engineering Society and North American Vascular Biology Society. Dr. Dai serves as a reviewer for Journal of Biomechanical Engineering, American Journal of Physiology and Journal of Vascular Surgery.

Research Activities:
Vascular endothelium plays an increasingly important role in many physiological and pathological processes in cardiovascular system. The functional phenotypes of the vascular endothelium are constantly modulated by its surrounding environments, including interactions with blood components, smooth muscle cells, extracellular matrix and biomechanical forces. Dysfunctional endothelium can contribute to the pathogenesis of many vascular diseases such as inflammation, thrombosis, atherosclerosis and failure of vascular graft. The mission of Vascular Bioengineering Laboratory is to integrate bioengineering approaches with vascular biology to understand how endothelial cell interacting with its environment and its role in the blood vessel regeneration and vascular disease processes, and to generate better designs in tissue engineering of vascular graft and microvasculature for organ regeneration.

Currently, the research programs in the laboratory focus on three goals: (1) To understand how biomechanical forces regulate vascular functions, and to identify targets associated with specific cellular phenotype in diseased blood vessels and develop technologies for targeted drug delivery and molecular imaging of those vasculatures; (2) To develop 3-D cell printing technology for vascular tissue engineering applications, such as engineering tissue structures with adequate vascular perfusion and designing optimal conditions for blood vessel regeneration; (3) To develop technology to differentiate stem cells toward vascular lineage in particular arterial and venous endothelial cells, and to apply them in tissue engineering of vascular graft. To accomplish these research programs, we will use multidisciplinary approaches combining various methods including engineering design, experimental and computational fluid mechanics, micro-fabrication, cellular and molecular techniques. There are excellent opportunities for collaboration with our BME faculty in the field of tissue engineering, biomaterials, cell mechanics as well as our colleagues at Albany Medical College.

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Education Ph.D., Harvard Medical School - Massachusetts Institute of Technology Biomedical Engineering
M.S., Beijing University Biomechanics
B.S., Beijing University Mechanical Engineering
Suvranu De
Name: Suvranu De
Title:Department Head, Professor and Director, CeMSIM
Department Biomedical Engineering IT and Web Science Mechanical Aerospace and Nuclear Engineering
School Engineering
Center Center for Modeling, Simulation and Imaging in Medicine (CEMSIM)
Website:http://www.rpi.edu/~des/
Bio
  • Professor, MANE, BME and ITWS Departments, RPI
    2011 - present
  • Director, Center for Modeling, Simulation and Imaging in Medicine (CeMSIM), RPI
    2010 - present
  • Associate Professor, MANE, BLE and ITWS Departments, RPI
    2007 - 2010
  • Assistant Professor, MANE Department, RPI
    2002 - 2007
  • Research Scientist, Research Laboratory of Electronics, MIT
    Oct 2000 - Dec 2001
    • Fast computational tools for MEMS design
    • Multimodal medical simulations
  • Graduate Research Assistant, Department of Mechanical Engineering, MIT
    May 1997 - Sep 2000
    • Meshfree Methods: Method of Finite Spheres
    • Virtual environments for medical simulation
    • Biomechanics of touch
  • Research Associate, Department of Mechanical Engineering, Indian Institute of Science, Bangalore
    Sept 1993 - Jan 1995
    • FE algorithms for large deformation elastoplastic boundary value problems
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Education Sc.D. Massachusetts Institute of Technology
Scholarly Works:
  • The method of finite spheres (2000)
  • De, S. and Bathe, K. J., The method of finite spheres with improved numerical integration(2001)
  • De, S. and Bathe, K. J., Towards an efficient meshless computational technique: the method of finite spheres (2001)
  • Displacement/ pressure mixed interpolation in the method of finite spheres (2001)
  • On the method of finite spheres in applications: towards the use with ADINA and a surgical simulator (2003)
  • Hierarchical tree-based discretization in the method of finite spheres (2003)
  • Efficient computation of drag forces on micro-machined devices using a boundary integral equation-based solver (2003)
  • Physically-based real time simulation of soft tissues in multimodal medical simulations
  • Towards an automatic discretization scheme for the method of finite spheres and its coupling with the finite element method
  • The role of haptics in medical simulations
  • A unified approach to multimodal rendering of heterogeneous scenes using point clouds
  • A finite element mode
Jonathan S. Dordick
Name: Jonathan S. Dordick
Title:Howard P. Isermann Professor and Director of the Center for Biotechnology and Interdisciplinary Studies
Department Biomedical Engineering Chemical and Biological Engineering Materials Science and Engineering
School Engineering
Center Center for Biotechnology and Interdisciplinary Studies (CBIS)
Website:http://enzymes.che.rpi.edu/
Bio Dordick joined the Rensselaer faculty as the chair of the Department of Chemical Engineering in 1998 and is also the Howard P. Isermann Professor. He spent nine years at the University of Iowa. He joined their staff in 1987 as a member of the Department of Chemical and Biochemical Engineering and was promoted to associate professor in 1991 and to full professor in 1994. He served as department chair from 1995 to 1998. He also served as associate director of the Center for Biocatalysis and Bioprocessing at the University of Iowa and held a joint position in the university's Department of Medicinal and Natural Products Chemistry in the College of Pharmacy. Dordick is the associate editor for Biotechnology and Bioengineering (1996 to present), and is a member of the editorial boards for several publications, including Enzyme and Microbial Technology (1993 to present); the Journal of Industrial Microbiology (1996 to 2000); the Journal of Environmental Polymer Degradation (1996 to present); Metabolic Engineering (
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Education Ph.D. Biochemical Engineering (Massachusetts Institute of Technology, 1983), M.S. Biochemical Engineering (Massachusetts Institute of Technology, 1983), B.A. Biochemistry and Chemistry (Brandeis University, 1980)
Scholarly Works:
  • Structural diversity of peroxidase-catalyzed oxidation products of o-Methoxyphenols (2004)
  • Silica Nanoparticules Size Influences the Structure and Enzymatic Activity o Adsorbed Lysozyme (2004)
  • Periplasmic expression as a basis for whole cell kinetic screening of unnatural enzyme reactivities (2004)
  • Hydration of Enzyme in nonaqueous media is consistent with solvent dependence of its activity (2004)
  • Combinatorial Formulation of Biocatalyst Preparations for Increased Activity in Organic Solvents: Salt Activation of Penicillin Amidase (2004)
  • Biocompatibility of chemoenzymatically derived dextran-acrylate hydrogels (2004)
  • Solid-phase peptide synthesis by ion-paired alpha-chymotrypsin in nonaqueous media (2003)
  • Si-Nanocolumns as Unique Nanostructured Supports for Enzyme Immobilization (2003)
  • Self-assembled lipid nanotube materials from synthetic glycolipids (2003)
  • Multienzyme Catalysis in Microfluidic Biochips (2003)
  • Microfluidic Peroxidase Biochip for Polyphenol Synthesis (2003)
  • Influence of Different S
Stanley M Dunn
Name: Stanley M Dunn
Title:Professor, Vice Provost, Dean Graduate Education
Department Biomedical Engineering
School Engineering
Bio Dunn joins Rensselaer from his position as professor of biomedical engineering and the Paul S. and Mary W. Monroe Faculty Scholar at Rutgers University, where he was also an associate dean of the School of Engineering and associate director of the university’s Center for Innovative Ventures for Emerging Technologies, a center to promote research translation and industry-university relationships.

Since joining Rutgers in 1986, Dunn has served as the graduate program director, vice chair, acting chair, and interim chair of Rutgers’ Department of Biomedical Engineering. He also played a key role in growing the department’s undergraduate enrollment.

Dunn’s experience includes developing universitywide initiatives in such areas as packaging engineering, water resource management, and homeland security. He also has extensive experience building academic programs, including overseeing the country’s first engineering-based clinical training program in prosthetics and orthotics. Dunn has mentored 14 Ph.D. students, 23 M.S. students, and many undergraduate students. These students have come from biomedical engineering, electrical and computer engineering, computer science, mathematics, dentistry, as well as the M.D./Ph.D. program.

The author of three books and 150 papers on different subjects including digital subtraction radiography, Dunn is a fellow of the American Institute of Medical and Biological Engineering. He is the founding editor-in-chief of the Journal of Applied Packaging Research, and has served as an editor and officer of several journals and professional organizations. He is co-organizer of an NSF-funded workshop on Nanotechnology in Biology to be held in October 2008.

Dunn received two undergraduate degrees from Drexel University, and went on to earn his master’s degree and doctorate in computer science from the University of Maryland. He also earned a doctorate in imaging science from Vrije Universiteit Amsterdam in the Netherlands.
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Ryan Gilbert
Name: Ryan Gilbert
Title:Assistant Professor
Department Biomedical Engineering
School Engineering
Center Center for Biotechnology and Interdisciplinary Studies (CBIS)
Website:http://www.rjgilbertlab.com/people/
Bio While an undergraduate at the University of Michigan, Dr. Gilbert received a National Science Foundation (NSF) research experience for undergraduates (REU) summer fellowship to study hybridoma cell viability at the Massachusetts Institute of Technology in the laboratory of Dr. Gregory Stephanopoulos. This experience fueled his desire to pursue research as a career. During his Ph.D. studies in the laboratory of Dr. Ravi Bellamkonda, he determined how sulfation patterns of glycosaminoglycans within chondroitin sulfate proteoglycans varied after central nervous system injury. Then, he fabricated novel biomaterial scaffolds that consisted of various types of sulfated and unsulfated glycosaminoglycans. Neurons were placed within these models to determine which glycosaminoglycan(s) most inhibited axonal extension from dorsal root ganglia.

After receiving his Ph.D., Dr. Gilbert accepted an Assistant Professor position at Michigan Technological University. While there, his research focus shifted towards the development of novel biomaterial constructs for tissue repair. Various constructs have been employed within experimental models of bone and lymph injury. However, the main focus of his research is in the development of biomaterials for the treatment of acute and chronic phase spinal cord injury. Dr. Gilbert’s current research is supported in part by the National Institutes of Health (NIH), and past research support was funded by NIH, the Department of Energy (DOE), and commercialization initiatives from the State of Michigan. Work from Dr. Gilbert’s laboratory is featured on two recent journal covers, and a 2009 Journal of Neural Engineering article from his laboratory was selected for the journal’s “Highlights” of 2009. Dr. Gilbert is an ad hoc reviewer for several biomaterial, biomedical engineering, and neuroscience journals, as well as an ad hoc grant reviewer for funding agencies (NSF, Department of Veterans Affairs). Dr. Gilbert is a member of the Society for Biomaterials (SFB), Biomedical Engineering Society (BMES), and the Society for Neuroscience (SFN). In addition to his research efforts, Dr. Gilbert is active in the development of undergraduate curricula and research experiences for undergraduates. Undergraduates from his laboratory have won prestigious undergraduate awards (Barry M. Goldwater Scholarship, NSF Graduate Student Fellowship), been first authors on scientific journal articles, successfully gained employment at biomedical companies (Boston Scientific, Epic, Plexus), and gained entry into graduate, medical, or law schools. For his teaching efforts, Dr. Gilbert was named a finalist for the Michigan Technological University distinguished teaching award and is active in improving classroom experiences for students.
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Education Ph.D., Case Western Reserve University Biomedical Engineering B.S.E., University of Michigan – Ann Arbor Chemical Engineering
Juergen Hahn
Name: Juergen Hahn
Title:Professor
Department Biomedical Engineering Chemical and Biological Engineering
School Engineering
Center Center for Automation Technologies and Systems (CATS) Center for Biotechnology and Interdisciplinary Studies (CBIS)
Website:http://homepages.rpi.edu/~hahnj/group.html
Bio Juergen Hahn was born in Grevenbroich, Germany, in 1971. He received his diploma degree in engineering from RWTH Aachen, Germany, in 1997, and his MS and Ph.D. degrees in chemical engineering from the University of Texas, Austin, in 1998 and 2002, respectively. He was a post-doctoral researcher at the chair for process systems engineering at RWTH Aachen, Germany, before joining the department of chemical engineering at Texas A&M University, College Station, in 2003. He joined the Rensselaer Polytechnic Institute as a professor in 2012 and currently holds appointments in the department of biomedical engineering and the department of chemical & biological engineering. His research interests include systems biology and process modeling and analysis with over 60 articles and book chapters in print. Dr. Hahn is a recipient of a Fulbright scholarship (1995/96), received the Best Referee Award for 2004 from the Journal of Process Control, the CPC 7 Outstanding Contributed Paper Award in 2006, and was named the 2010 CAST Outstanding Young Researcher. He is currently serving as an associate editor for the journals Automatica, Control Engineering Practice, and the Journal of Process Control.
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Education
Ph.D.,University of Texas at Austin,  (2002)
M.S.,University of Texas at Austin,(1998)
Diploma,    RWTH Aachen, Germany, (1997)
Scholarly Works:
  • Z. Huang, C. Moya, A. Jayaraman, and J. Hahn. Using the Tet-On System to Develop a Procedure for Extracting Transcription Factor Activation Dynamics. Molecular BioSystems 6, No. 10, pp. 1883-1889 (2010)
  • C. Qu and J. Hahn. Computation of Arrival Cost for Moving Horizon Estimation via Unscented Kalman Filtering. Journal of Process Control 19, No. 2, pp. 358-363 (2009).
  • Z. Huang, F. Senocak, A. Jayaraman, and J. Hahn. Integrated Modeling and Experimental Approach for Determining Transcription Factor Profiles from Fluorescent Reporter Data. BMC Systems Biology 2:64 (2008).
  • Y. Chu and J. Hahn. Integrating Parameter Selection with Experimental Design under Uncertainty for Nonlinear Dynamic Systems. AIChE Journal 54, No. 9, pp. 2310-2320 (2008).
  • Y. Chu, A. Jayaraman, and J. Hahn. Parameter Sensitivity Analysis of IL-6 Signaling Pathways. IET Systems Biology 1, No. 6, pp. 342-352 (2007).
  • A.K. Singh and J. Hahn. Sensor Location for Stable Nonlinear Dynamic Systems: Multiple Sensor Case. Industrial & Engineering Chemistry Research 45, No. 10, pp. 3615-3623 (2006).
Recognitions:
  • Associate Editor, Journal of Process Control 2010-
  • Associate Editor, Automatica 2011-
  • Associate Editor, Control Engineering Practice 2007-

  • AIMBE Fellow, 2013
  • CAST Outstanding Young Researcher Award, 2010
  • Ray Nesbitt Development Professorship II, 2010
  • Keller Faculty Fellowship,2008
  • Brockett Professorship, 2008
  • CPC 7 Outstanding Contributed Paper Award, 2006
  • Outstanding Reviewer, Automatica, 2005, 2006, 2007
  • Best Referee Award, Journal of Process Control, 2004
  • William S. Livingston Graduate Fellowship, 2001
  • David Bruton, Jr. Graduate Fellowship, 2000
  • Springorum Medal, 1998
  • Fulbright Scholarship, 1995