Curt Breneman

Dean of the School of Science, Professor and Director, Rensselaer Exploratory Center for Cheminformatics Research (RECCR)


Curt Breneman was born in Santa Monica, California in 1956, and went on to earn a B.S. in Chemistry at UCLA in 1980 followed by a Ph.D. in Chemistry at UC Santa Barbara (with an emphasis on Physical Organic and Computational Chemistry) in 1987. Following two years of post-doctoral research at Yale University, Dr. Breneman joined the faculty of the Department of Chemistry at Rensselaer Polytechnic Institute (RPI) and began a program in molecular recognition and computational chemistry based on his concept of "Transferable Atom Equivalents", or TAEs, as building blocks for describing the electronic and reactive character of molecules. Dr. Breneman currently holds the rank of Full Professor in the RPI Department of Chemistry and Chemical Biology, and is the Director of the NIH RECCR Center. He later served as Head of the Department of Chemistry & Chemical Biology and now as Dean of the School of Science. The Breneman research group primarily specializes in the development of new molecular property descriptors and machine learning methods that can be applied to a diverse set of physical and biochemical problems. Of paramount interest are methods that can increase the information content of molecular descriptors, and machine learning techniques that can exploit this data for the creation of fully validated, predictive property models. Current application areas include pharmaceutical ADME prediction, virtual high-throughput screening of drug candidates, protein chromatography modeling (HIC and ion-exchange), as well as polymer property prediction.

Other affililations: Information Technology and Web Science


Other Focus Areas

Cheminformatics, Materials Informatics, Drug Discovery Software, Computational ADME/Tox, Data Analytics


The following is a selection of recent publications in Scopus. Curt Breneman has 106 indexed publications in the subjects of Chemistry, Computer Science, Biochemistry, Genetics and Molecular Biology.

Yu Xiu, Ni Zhang, Pranesha Prabhakaran, Sungho Jang, Qipeng Yuan, Curt M. Breneman, Gyoo Yeol Jung, Wanwipa Vongsangnak, Mattheos A.G. Koffas
Synthetic and Systems Biotechnology
, 7
, 2022
, pp.1148-1158
Karthik Pushpavanam, Subhadeep Dutta, Ni Zhang, Tyree Ratcliff, Tomasz Bista, Thaddeus Sokolowski, Eric Boshoven, Stephen Sapareto, Curt M. Breneman, Kaushal Rege
Bioconjugate Chemistry
, 32
, 2021
, pp.1984-1998
J. M. Shoulder, E. L. Ashenafi, C. M. Breneman, M. C. Nyman
SAR and QSAR in Environmental Research
, 30
, 2019
, pp.229-245
Zhuo Zhen, Thrimoorthy Potta, Matthew D. Christensen, Eshwaran Narayanan, Kapil Kanagal, Curt M. Breneman, Kaushal Rege
ACS Biomaterials Science and Engineering
, 5
, 2019
, pp.654-669
Alexander New, Curt Breneman, Kristin P. Bennett
Proceedings of the International Joint Conference on Neural Networks
, 2018-July
, 2018
Yanhui Huang, He Zhao, Yixing Wang, Tyree Ratcliff, Curt Breneman, L. Catherine Brinson, Wei Chen, Linda S. Schadler
Journal of Applied Physics
, 122
, 2017
Sunil P. Badal, Tyree D. Ratcliff, Yi You, Curt M. Breneman, Jacob T. Shelley
Journal of the American Society for Mass Spectrometry
, 28
, 2017
, pp.1013-1020
Michael Bell, Timothy Krentz, J. Keith Nelson, Linda Schadler, Ke Wu, Curt Breneman, Su Zhao, Henrik Hillborg, Brian Benicewicz
Journal of Colloid and Interface Science
, 495
, 2017
, pp.130-139
Zhuo Zhen, Thrimoorthy Potta, Nicholas A. Lanzillo, Kaushal Rege, Curt M. Breneman
Combinatorial Chemistry and High Throughput Screening
, 20
, 2017
, pp.41-55
K. Wu, N. Sukumar, N. A. Lanzillo, C. Wang, Ramamurthy “Rampi” Ramprasad, R. Ma, A. F. Baldwin, G. Sotzing, C. Breneman
Journal of Polymer Science, Part B: Polymer Physics
, 54
, 2016
, pp.2082-2091

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