Robert Linhardt

Ann and John H. Broadbent, Jr. ’59 Senior Constellation Professor of Biocatalysis and Metabolic Engineering

About

Robert J. Linhardt received his Ph.D. degree from the Johns Hopkins University (1979) and was a postdoctoral student with Professor Robert Langer at the Massachusetts Institute of Technology (1979-1982) and served on the faculty of University of Iowa from 1982-2003. He is currently the Ann and John H. Broadbent, Jr.'59 Senior Constellation Professor of Biocatalysis and Metabolic Engineering at Rensselaer Polytechnic Institute, holding joint appointments in the Departments of Chemistry and Chemical Biology, Biology, Chemical and Biological Engineering, and Biomedical Engineering. He is an Adjunct Professor of Orthopedics at the Icahn School of Medicine, Mount Sinai, NY.

Education & Training

Postdoctorate resesarch – Massachusetts Institute of Technology, Langer Lab
1979-1982 Biochemical Engineering and Bioorganic Chemistry

Ph.D. The Johns Hopkins University
1979 Organic Chemistry

M.A. The Johns Hopkins University
1977 Organic Chemistry

B.S. Marquett University
1975 Chemistry

Professional Experience

  • Ann and John H. Broadbent Senior Constellation Chair in Biocatalysis and Metabolic Engineering, Professor of Chemistry, Biology and Chemical and Biological Engineering, Rensselaer Polytechnic Institute (RPI), 2003 - present
  • Acting Director, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 7/06-8/08
  • Adjunct Professor, Orthopaedics, Mount Sinai School of Medicine, NY, NY, 1/15
  • Adjunct Professor of Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY, 7/05- present
  • F. Wendell Miller Distinguished Professor of Chemistry, 7/99-8/03
  • F. Wendell Miller Distinguished Professor of Medicinal and Natural Products Chemistry and Professor of Chemical and Biochemical Engineering, 5/96-8/03
  • Professor of Medicinal and Natural Products Chemistry, 5/90-8/03
  • Visiting Professor, University of California, San Diego, Cancer Center and the La Jolla Cancer Research Foundation, 1/92-9/92
  • Associate Professor of Medicinal and Natural Products Chemistry, 7/86-4/90
  • Assistant Professor of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa (UI), 7/82-6/86
  • Industrial Consultant in the area of biocatalysis, biopolymers, carbohydrate chemistry and drug delivery, 1/81-present
  • Research Associate, Biochemical Engineering, Department of Applied Biological Sciences and Harvard-MIT Joint Program in Biomedical Research at the Whitaker College of Health Sciences and Technology, Massachusetts Institute of Technology, 6/79-6/82
  • Research/Teaching Assistant, Department of Chemistry, The Johns Hopkins University, 9/75-5/79
Other affililations: Biological Sciences, Chemical and Biological Engineering, Biomedical Engineering

Research

Research in the Linhardt lab focuses on complex carbohydrates. Glycoprotein, proteoglycans, and other glycoconjugates are prepared by fermentation using recombinant technology, extraction from tissues, or by chemical and enzymatic synthesis. After determining the structure of these molecules, his group studies their biological activities. Research in the Linhardt group has many focuses, including the mapping of the glycome, embryonic stem cell proteoglycan glycomics, structural biology studies, GAG sequencing using mass spectrometry (MS), the specificity and kinetics of protein-carbohydrate interactions, the medical application of nanomaterials, and chemical and enzymatic synthesis of carbohydrates.

More information about Professor Linhardt's research

Other Focus Areas

Glycoscience, Biocatalysis, Metabolic Engineering, Nanobiotechnology, Analytical and Bioanalytical Chemistry, Chemoenzymatic Synthesis, Biochemistry and Chemical Biology, Biotechnology and Biomaterials, Organic, Medicinal and Drug Discovery, Polymers, Materials and Energy

Recognition

Professional Societies

  • Society for Glycobiology
  • American Society for Matrix Biology
  • American Society of Biochemistry and Molecular Biology
  • American Chemical Society, Divisions of Medicinal Chemistry, Biotechnology and Carbohydrate Chemistry
  • American Association of Pharmaceutical Scientists
  • American Association of Colleges of Pharmacy
  • American Association for the Advancement of Science – AAAS Fellow

National Appointments

  • Editorial Boards
  • The Journal of Biological Chemistry 1995-2000, 2005-2011
  • American Journal of Analytical Chemistry 2010-
  • Molecules 2009-
  • Polymers 2009-
  • Cell Health and Cytoskeleton 2008-
  • International Journal of Carbohydrate Chemistry 2008-
  • Organic Synthesis 2008-
  • Biochemistry Research International 2007-
  • Nanotechnology, Science and Applications 2007-
  • Open Glycoscience (Editor-in-Chief) 2007-
  • Glycobiology 2006-
  • Current Organic Synthesis (Regional Editor) 2002-
  • Mini Reviews in Organic Chemistry (Regional Editor) 2002-
  • Journal of Carbohydrate Chemistry 1995-
  • Analytical Biochemistry 1991-1997, 2001-
  • Carbohydrate Research 1990-2002
  • Applied Biochemistry and Biotechnology 1985-
  • Committees and Memberships:
  • 2015 Fellow-National Academy of Inventors
  • 2012 Chair–Proteoglycans Gordon Conference
  • 2009 Synthetic and Biological Chemistry B, Biological Chemistry and (Macromolecular Biophysics ad hoc member
  • 2008 FDA Adverse Reactions Working Group
  • 2008-2009 USP Advisory Committee on Heparin
  • 2006 Synthetic and Biological Chemistry A Study Section ad hoc member
  • 2004 President's Council on Competitiveness (National Initiative on Innovation, Skills subcommittee member)
  • 2004 Thrombosis and Hemostasis Study Section ad hoc member
  • 2003 Bioorganic and Natural Products Study Section ad hoc member
  • 1988 National Institutes of Health, Pharmacology Special Study Section
  • 1987 National Academy of Sciences Interacademy Exchange Scientist to Russia and the Ukraine
Awards & Honors

 

  • 2019 Karl Meyer Award from the Society for Glycobiology
  • 2015 Elected to National Academy of inventors (NAI) Fellow
  • 2010 Melville L. Wolfrom Award Award from the American Chemical Society - For outstanding service to the Carbohydrate Division and to the field of carbohydrate chemistry
  • 2010 Elected to the rank of American Association for the Advancement of Science (AAAS) Fellow
  • 2009 Scientific American 10 - Recognized for contributions to American science and technology
  • 2003 RPI Ann and John H. Broadbent Senior Constellation Chair in Biocatalysis and Metabolic Engineering awarded
  • 2003 American Chemical Society Claude S. Hudson Award in Carbohydrate Chemistry
  • 1999 Volwiler Research Achievement Award sponsored by Abbott, awarded by the AACP
  • 1996 University of Iowa F. Wendell Miller Distinguished Professorship Awarded
  • 1994 Horace S. Isbell Award from the American Chemical Society, Division of Carbohydrate Chemistry - Given for excellence of contributions to carbohydrate chemistry and continuing promise of quality contributions
  • 1992 Iowa Regents Award for Faculty Excellence - Awarded for a sustained record of excellence across the spectrum of faculty endeavors
  • 1989 University of Iowa Excellence in Teaching Award
  • 1981 MIT Johnson & Johnson Postdoctoral Fellow - A competitive award given for exceptional biomedical research.
  • 1979 The Johns Hopkins University Ernst M. Marks Award - Presented for excellence in teaching and research in organic chemistry

 

Publications

For a complete list of Professor Linhardt's publications visit heparin.rpi.edu/papers

The following is a selection of recent publications in Scopus. Robert Linhardt has 1110 indexed publications in the subjects of Biochemistry, Genetics and Molecular Biology, Chemistry, and Materials Science.

Weihua Jin, Chenghui Lu, Yanan Zhu, Jing Zhao, Wenjing Zhang, Lianchun Wang, Robert J. Linhardt, Chunyu Wang, Fuming Zhang
Carbohydrate Polymers
, 299
, 2023
.
Friederike Eilts, Sarah Bauer, Keith Fraser, Jonathan S. Dordick, Michael W. Wolff, Robert J. Linhardt, Fuming Zhang
Carbohydrate Polymers
, 299
, 2023
.
Wenjing Zhang, Weihua Jin, Vitor H. Pomin, Fuming Zhang, Robert J. Linhardt
Frontiers in Molecular Biosciences
, 9
, 2022
.
Na Yan, Feifan Song, Yilan Ouyang, Duxin Li, He Tian, Lin Yi, Robert J. Linhardt, Zhenqing Zhang
Analytical Chemistry
, 94
, 2022
, pp.13000-13009
.
Yanlei Yu, Li Fu, Peng He, Ke Xia, Sony Varghese, Jonathan Dordick, Hong Wang, Fuming Zhang, Robert J. Linhardt
Carbohydrate Polymers
, 295
, 2022
.
Peipei Wang, Lianli Chi, Zhenqing Zhang, Hongmei Zhao, Fuming Zhang, Robert J. Linhardt
Carbohydrate Polymers
, 295
, 2022
.
Sophie Denamur, Thibault Chazeirat, Martyna Maszota-Zieleniak, Romain R. Vivès, Ahlame Saidi, Fuming Zhang, Robert J. Linhardt, François Labarthe, Sergey A. Samsonov, Gilles Lalmanach, Fabien Lecaille
Carbohydrate Polymers
, 293
, 2022
.
Xue Wang, Anna Christina Amason, Rebecca T. Miceli, Peng He, Yabin Lei, Ron Gabbard, Julie Ann Wieland, Robert J. Linhardt, David T. Corr, Richard A. Gross
Colloids and Surfaces A: Physicochemical and Engineering Aspects
, 648
, 2022
.
Gaganpreet Kaur, Yuefan Song, Ke Xia, Kevin McCarthy, Fuming Zhang, Robert J. Linhardt, Norman R. Harris
Glycobiology
, 32
, 2022
, pp.720-734
.
Christopher Yanucil, Dominik Kentrup, Isaac Campos, Brian Czaya, Kylie Heitman, David Westbrook, Gunars Osis, Alexander Grabner, Adam R. Wende, Julian Vallejo, Michael J. Wacker, Jose Alberto Navarro-Garcia, Gema Ruiz-Hurtado, Fuming Zhang, Yuefan Song, Robert J. Linhardt, Kenneth White, Michael S. Kapiloff, Christian Faul
Kidney International
, 102
, 2022
, pp.261-279
.

View All Scopus Publications

The Linhardt Research Labs

In response to the Heparin Contamination Crisis, our group partnered with several others to begin bioengineering Heparin from bacteria. Together with Dr. Liu of UNC, we successfully created a synthetic Heparin using enzymatic synthesis. Today, Dr. Linhardt is internationally known for his research on the study of bioactive carbohydrates, particularly the complex polysaccharide heparin.

heparin.rpi.edu

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