Dan Iascone

Biological Sciences
Assistant Professor

About

Dr. Iascone received his BA from the University of Pennsylvania. He completed his PhD training at Columbia University with Dr. Franck Polleux, where he developed tools to create the first complete synaptic maps of pyramidal neurons in work funded by an F31 NRSA. Dan completed his postdoctoral training at the University of Pennsylvania/HHMI with Dr. Amita Sehgal, where he investigated crosstalk between circadian rhythms and metabolism in obesity and cancer. This work was funded first by an F32 NRSA awarded by the NIMH BRAIN Initiative and later by an NIDDK K99/R00. Dr. Iascone joined the Department of Biological Sciences at Rensselaer Polytechnic Institute in 2026.

Education & Training

Ph.D. Columbia University, 2020 - Neurobiology & Behavior

B.A. University of Pennsylvania, 2013 - Cognitive Neuroscience

Postdoctoral Research & Training

Postdoctoral Fellow, University of Pennsylvania/HHMI, 2020-2026 - Chronobiology

Other affiliations: Center for Biotechnology and Interdisciplinary Studies

Research

In the brain, neuronal health and function rely upon a vast network of metabolic interactions with glia. These pathways, which execute an adaptive balance of anabolic support and waste processing, must be precisely timed to prevent long-term degeneration. The goal of my lab is to discover how the timing of neuron-glia metabolic coupling is controlled by sleep and the circadian clock, and how disruption of these processes contributes to aging/disease.

Recognition

Awards & Honors

2017 F31 National Research Service Award, NIH NINDS

2020 F32 National Research Service Award, NIH NIMH BRAIN Initiative

2025 K99/R00 Pathway to Independence Award, NIH NIDDK

Publications

The following is a selection of recent publications in Scopus. Dan Iascone has 15 indexed publications in the subjects of Medicine, Biochemistry, Genetics and Molecular Biology, Biochemistry, Genetics and Molecular Biology.

Clustered inputs engage dendritic nonlinearities and calcium signaling to support efficient place-field formation in CA1 pyramidal neurons
Simone Tasciotti, Daniel Maxim Iascone, Spyridon Chavlis, Luke A. Hammond, Yardena Katz, Attila Losonczy, Franck Polleux, Panayiota Poirazi
Cell Reports
, 45
, 2026
.
Tanycyte BMAL1 regulates high-fat diet weight gain and shapes arcuate neurogenesis in female mice
Daniel Maxim Iascone, Pavel Pivarshev, Jianing Yang, Mariela Lopez Valencia, Sara B. Noya, Hongtong Lin, Corey D. Holman, Ron C. Anafi, Joseph L. Bedont, Amita Sehgal
Cell Reports
, 45
, 2026
.
Bezafibrate improves mitochondrial function, blood-brain barrier integrity, and social deficits in models of 22q11.2 deletion syndrome
Alexis M. Crockett, Maria C. Vélez Colόn, Hania Kebir, Frances M. Smith, Daniel M. Iascone, Brianna Ciesielski, Sergei Koshkin, Andrew D. Patterson, Adam J. Rossano, Amita Sehgal, Stewart A. Anderson, Jorge Ivan Alvarez
Science Translational Medicine
, 17
, 2025
.
Author Correction: BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets (Nature Methods, (2023), 20, 6, (824-835), 10.1038/s41592-023-01848-5)
Linus Manubens-Gil, Zhi Zhou, Hanbo Chen, Arvind Ramanathan, Xiaoxiao Liu, Yufeng Liu, Alessandro Bria, Todd Gillette, Zongcai Ruan, Jian Yang, Miroslav Radojević, Ting Zhao, Li Cheng, Lei Qu, Siqi Liu, Kristofer E. Bouchard, Lin Gu, Weidong Cai, Shuiwang Ji, Badrinath Roysam, Ching Wei Wang, Hongchuan Yu, Amos Sironi, Daniel Maxim Iascone, Jie Zhou, Erhan Bas, Eduardo Conde-Sousa, Paulo Aguiar, Xiang Li, Yujie Li, Sumit Nanda, Yuan Wang, Leila Muresan, Pascal Fua, Bing Ye, Hai Yan He, Jochen F. Staiger, Manuel Peter, Daniel N. Cox, Michel Simonneau, Marcel Oberlaender, Gregory Jefferis, Kei Ito, Paloma Gonzalez-Bellido, Jinhyun Kim, Edwin Rubel, Hollis T. Cline, Hongkui Zeng, Aljoscha Nern, Ann Shyn Chiang, Jianhua Yao, Jane Roskams, Rick Livesey, Janine Stevens, Tianming Liu, Chinh Dang, Yike Guo, Ning Zhong, Georgia Tourassi, Sean Hill, Michael Hawrylycz, Christof Koch, Erik Meijering, Giorgio A. Ascoli, Hanchuan Peng
Nature Methods
, 21
, 2024
, pp.1959
.
Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells
Daniel Maxim Iascone, Xue Zhang, Patricia Brafford, Clementina Mesaros, Yogev Sela, Samuel Hofbauer, Shirley L. Zhang, Sukanya Madhwal, Kieona Cook, Pavel Pivarshev, Ben Z. Stanger, Stewart Anderson, Chi V. Dang, Amita Sehgal
Proceedings of the National Academy of Sciences of the United States of America
, 121
, 2024
.
BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets
Linus Manubens-Gil, Zhi Zhou, Hanbo Chen, Arvind Ramanathan, Xiaoxiao Liu, Yufeng Liu, Alessandro Bria, Todd Gillette, Zongcai Ruan, Jian Yang, Miroslav Radojević, Ting Zhao, Li Cheng, Lei Qu, Siqi Liu, Kristofer E. Bouchard, Lin Gu, Weidong Cai, Shuiwang Ji, Badrinath Roysam, Ching Wei Wang, Hongchuan Yu, Amos Sironi, Daniel Maxim Iascone, Jie Zhou, Erhan Bas, Eduardo Conde-Sousa, Paulo Aguiar, Xiang Li, Yujie Li, Sumit Nanda, Yuan Wang, Leila Muresan, Pascal Fua, Bing Ye, Hai yan He, Jochen F. Staiger, Manuel Peter, Daniel N. Cox, Michel Simonneau, Marcel Oberlaender, Gregory Jefferis, Kei Ito, Paloma Gonzalez-Bellido, Jinhyun Kim, Edwin Rubel, Hollis T. Cline, Hongkui Zeng, Aljoscha Nern, Ann Shyn Chiang, Jianhua Yao, Jane Roskams, Rick Livesey, Janine Stevens, Tianming Liu, Chinh Dang, Yike Guo, Ning Zhong, Georgia Tourassi, Sean Hill, Michael Hawrylycz, Christof Koch, Erik Meijering, Giorgio A. Ascoli, Hanchuan Peng
Nature Methods
, 20
, 2023
, pp.824-835
.
TreeMoCo: Contrastive Neuron Morphology Representation Learning
Hanbo Chen, Jiawei Yang, Daniel Maxim Iascone, Lijuan Liu, Lei He, Hanchuan Peng, Jianhua Yao
Advances in Neural Information Processing Systems
, 35
, 2022
.
The Lineage before Time: Circadian and Nonclassical Clock Influences on Development
Joseph Lewis Bedont, Daniel Maxim Iascone, Amita Sehgal
Annual Review of Cell and Developmental Biology
, 36
, 2020
, pp.469-509
.
Whole-Neuron Synaptic Mapping Reveals Spatially Precise Excitatory/Inhibitory Balance Limiting Dendritic and Somatic Spiking
Daniel Maxim Iascone, Yujie Li, Uygar Sümbül, Michael Doron, Hanbo Chen, Valentine Andreu, Finola Goudy, Heike Blockus, Larry F. Abbott, Idan Segev, Hanchuan Peng, Franck Polleux
Neuron
, 106
, 2020
, pp.566-578.e8
.
Pum2 Shapes the Transcriptome in Developing Axons through Retention of Target mRNAs in the Cell Body
José C. Martínez, Lisa K. Randolph, Daniel Maxim Iascone, Helena F. Pernice, Franck Polleux, Ulrich Hengst
Neuron
, 104
, 2019
, pp.931-946.e5
.

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