Jennifer M. Hurley

Richard Baruch M.D. Career Development Chair, Biological Sciences

Dr. Jennifer Hurley received her B.S. from Juniata College in 2004 in molecular biology. She did her Ph.D. at Rutgers/UMDNJ with Drs. Nancy Woychik and Masayori Inouye, studying the function of Toxin-Antitoxin modules in bacteria. She was recognized by the American Society for Biochemistry and Molecular Biology for excellence in research for her study of the HigBA toxin-antitoxin module. Jennifer did her Postdoctoral fellowship at the Geisel School of Medicine at Dartmouth with Drs. Jay Dunlap and Jennifer Loros, investigating the relationship between the core proteins and the output of the circadian clock in Neurospora. Her Fellowship was funded by the Ruth Kirschstein National Research Service Award from the National Institute of General Medical Sciences and she received a Perkins award for her contributions to Neurospora research. Dr. Hurley joined the Department of Biological Sciences at Rensselaer Polytechnic Institute in 2015 as an Assistant Professor. Dr. Hurley's research focus is on the fundamental mechanisms underlying circadian rhythms. Circadian rhythms are an important component in understanding how organisms function within the photoperiodic world that we live in; defects in the circadian clock or disruptions in circadian rhythms are linked to a wide range of sleep, metabolic and psychological disorders in humans. Her lab investigates the relationship between the core clock mechanism and the output that the clock controls using a combination of molecular genetics and biochemical techniques as well as a biostatistical/computational approach using whole genome scale data.

Education

B.S. Molecular Biology and Politics, Juniata College (2004); Ph.D. Molecular Genetics, Microbiology and Immunology, Rutgers/UMDNJ (2009); P.Ph.D. Genetics and Biochemistry, Dartmouth (2015)

Research Focus
  • Circadian Rhythms
  • Neurospora
  • Macrophages
  • Immunology
  • Protein Structure/Function Relationships
  • Systems Biology
  • Ecology
Select Works
  • Representative work listed below. Full Bibliography at http://www.ncbi.nlm.nih.gov/sites/myncbi/jennifer.hurley.1/bibliography/47796157/public/?sort=date&direction= descending
  • De Los Santos, H., Collins, E.J., Mann, C., Sagan, A.W., Jankowski, M.S., Bennett, K.P., Hurley, J.M. Bioinformatics 2019 ECHO: an Application for Detection and Analysis of Oscillators Identifies Metabolic Regulation on Genome-Wide Circadian Output.
  • Pelham JF, Mosier AE, Hurley JM. Methods Enzymology 2018 Characterizing Time-of-Day Conformational Changes in the Intrinsically Disordered Proteins of the Circadian Clock.
  • Hurley J.M., Jankowski, M.S., De Los Santos, H., Crowell A.M., Fordyce S.B., Zucker, J.D., Kumar, N., Purvine, S.O., Robinson, E.W., Shukla, A., Zink, E., Cannon, W.R., Baker, S.E., Loros, J.J., Dunlap, J.C. Cell Systems 2018 Circadian proteomic analysis uncovers mechanisms of post-transcriptional regulation in metabolic pathways.
  • Coldsnow, K.D., Relyea, R.A., and Hurley, J.M. Ecology and Evolution 2017 Evolution to environmental contamination ablates the circadian clock of an aquatic sentinel species.
  • Hurley J.M., Dasgupta A., Emerson J.M., Zhou X., Ringelberg C.S., Knabe N., Lipzen A., Lindquist E., Daum C., Barry K., Grigoriev I.V., Smith K., Galagan J., Bell-Pedersen D., Freitag M., Cheng C., Loros J.J., Dunlap J.C. PNAS 2014 Analysis of clock regulated genes in Neurospora reveals widespread post-transcriptional control of metabolic potential.
  • Hurley, J.M., and Dunlap, J.C. Nature 2013 Cell biology: A fable of too much too fast.
  • Hurley, J.M., Larrondo, L.F., Loros, J.J., and Dunlap, J.C. Molecular Cell 2013 Conserved RNA helicase FRH acts nonenzymatically to support the intrinsically disordered Neurospora clock protein FRQ.