Jennifer M. Hurley

Richard Baruch M.D. Career Development Chair, Biological Sciences

Dr. Jennifer Hurley received her B.S. from Juniata College in 2004 in molecular biology. She did her Ph.D. at Rutgers/UMDNJ with Drs. Nancy Woychik and Masayori Inouye, studying the function of Toxin-Antitoxin modules in bacteria. She was recognized by the American Society for Biochemistry and Molecular Biology for excellence in research for her study of the HigBA toxin-antitoxin module. Jennifer did her Postdoctoral fellowship at the Geisel School of Medicine at Dartmouth with Drs. Jay Dunlap and Jennifer Loros, investigating the relationship between the core proteins and the output of the circadian clock in Neurospora. Her Fellowship was funded by the Ruth Kirschstein National Research Service Award from the National Institute of General Medical Sciences and she received a Perkins award for her contributions to Neurospora research. Dr. Hurley joined the Department of Biological Sciences at Rensselaer Polytechnic Institute in 2015 as an Assistant Professor. Dr. Hurley's research focus is on the fundamental mechanisms underlying circadian rhythms. Circadian rhythms are an important component in understanding how organisms function within the photoperiodic world that we live in; defects in the circadian clock or disruptions in circadian rhythms are linked to a wide range of sleep, metabolic and psychological disorders in humans. Her lab investigates the relationship between the core clock mechanism and the output that the clock controls using a combination of molecular genetics and biochemical techniques as well as a biostatistical/computational approach using whole genome scale data.


B.S. Molecular Biology and Politics, Juniata College (2004); Ph.D. Molecular Genetics, Microbiology and Immunology, Rutgers/UMDNJ (2009); P.Ph.D. Genetics and Biochemistry, Dartmouth (2015)

Research Focus
  • Circadian Rhythms
  • Neurospora
  • Macrophages
  • Immunology
  • Protein Structure/Function Relationships
  • Systems Biology
  • Ecology
Select Works
  • Most recent work listed below. Full Bibliography at descending
  • Pelham JF, Mosier AE, Hurley JM. (2018) Methods Enzymol. 611, 503-529. Characterizing Time-of-Day Conformational Changes in the Intrinsically Disordered Proteins of the Circadian Clock.
  • Cannon, W.R., Zucker, J.D., Baxter, D.J., Kumar, N., Baker, S.E., Hurley, J.M. and Dunlap, J.C. (2018) Processes, 6(6), 63 Prediction of Metabolite Concentrations, Rate Constants and Post-Translational Regulation Using Maximum Entropy-Based Simulations with Application to Central Metabolism of Neurospora crassa
  • Coldsnow, K. D.G, Relyea, R. A., and Hurley, J. M. (2017) Evolution to environmental contamination ablates the circadian clock of an aquatic sentinel species. Ecology and Evolution Oct 28;7(23):10339-10349
  • Hughes, M.E. … Hurley, J.M. … Hogenesch, J.B. (2017) Guidelines for genome-scale analysis of circadian rhythms. JBR Nov 3;32(5):380-393
  • De Los Santos, H., Collins, E.J., Hurley, J.M., Bennett, K.P. (2017) Circadian Rhythms in Neurospora Exhibit Biologically Relevant Driven and Damped Harmonic Oscillations, In Press, Aug 20 455-463
  • Dekhang R., Wu C., Smith K.M., Lamb T.M., Peterson M., Bredeweg E.L., Ibarra O., Emerson J.M., Karunarathna, N., Lyubetskaya A., Azizi E., Hurley J.M., Dunlap J.C., Galagan J.E., Freitag M., Sachs M.S., and Bell-Pedersen D. G3 in press The Neurospora Transcription Factor ADV-1 Transduces Light Signals, and Temporal Information to Control Rhythms in Expression of Cell-Fusion Genes.
  • Hurley J.M.§ Loros J.J., Dunlap J.C§. (2016) Trends in the Biochemical Sciences Oct;41(10):834-46. Circadian Oscillators: Around the Transcription-Translation Feedback Loop and on to Output.