Jonathan Dordick

Institute Professor of Chemical and Biological Engineering and Professor of Biomedical Engineering and Biological Sciences
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About

Jonathan S. Dordick is Institute Professor of Chemical and Biological Engineering at Rensselaer Polytechnic Institute, with joint appointments in the Departments of Biomedical Engineering and Biological Sciences, and an adjunct appointment at Rockefeller University. Dr. Dordick is Co-Director of the Rensselaer-Mount Sinai Center for Engineering and Precision Medicine. He received his B.A. degree in Biochemistry and Chemistry from Brandeis University and his Ph.D. in Biochemical Engineering from the Massachusetts Institute of Technology. At Rensselaer, he served as the Vice President for Research, the Director of the Center for Biotechnology & Interdisciplinary Studies, and Department Chair. He is the co-Director of the Heparin Applied Research Center and is the Director of the SARS-CoV-2 Testing Laboratory for Rensselaer. Prior to joining Rensselaer, he was Professor of Chemical and Biochemical Engineering at the University of Iowa, where he also served as the founding Associate Director of the Center for Biocatalysis and Bioprocessing. He has served the biochemical engineering community as a previous chairman of the Biotechnology Division of the American Chemical Society and as an Editor of Biotechnology & Bioengineering. Professor Dordick is a member of the National Academy of Engineering and the National Academy of Inventors. He is a Fellow of the American Chemical Society, the American Association for the Advancement of Science, and the American Institute of Medical and Biological Engineers.

Education & Training

Ph.D. Massachusetts Institute of Technology
1986 Biochemical Engineering

M.S. Massachusetts Institute of Technology
1983 Biochemical Engineering

B.A. Brandeis University
1980 Biochemistry and Chemistry

Professional Experience

  • Institute Professor, Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY, 2021-present.
  • Co-Director, Rensselaer-Mount Sinai Center for Engineering and Precision Medicine, New York, NY, 2022-present.
  • Howard P. Isermann Professor, Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY, 1998-2021.
  • Senior Advisor to the President for Strategic Initiatives, Rensselaer Polytechnic Institute, Troy, NY, 2018-present.
  • Vice President for Research, Rensselaer Polytechnic Institute, Troy, NY, 2012-2018.
  • Guest Faculty Investigator (Visiting Professor), Rockefeller University, New York, NY, 2016-present.
  • Adjunct Professor, Icahn School of Medicine at Mount Sinai, New York, NY, 2014-2016.
  • Director, Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 2008-2012.
  • Joint Appointments in Departments of Biomedical Engineering and Biological Sciences
  • Visiting Research Scientist, Wadsworth Center, New York State Department of Health, 2007-2013.
  • Chairman, Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY, 1998-2002.
  • Professor and Chairman, Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA, 1995-1998. Joint appointment in the Department of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, Iowa City, IA, 1996-1998.
  • Professor, Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA, 1994-1995.
  • Associate Director, Center for Biocatalysis and Bioprocessing, University of Iowa, Iowa City, IA, 1990-1998.
  • Associate Professor, Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA, 1991-1994.
  • Assistant Professor, Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA, 1987-1991.
  • Postdoctoral Research Fellow, Tate & Lyle Group Research and Development, Reading, U.K., 1986-1987
Other affililations: Biomedical Engineering, Biological Sciences

Research

Dr. Dordick has made foundational contributions to enzyme technology, microscale cell culture engineering, drug discovery and human toxicology, and biomanufacturing. He pioneered the development of enzymatic and chemoenzymatic methods for new materials synthesis, initiated the new field of molecular bioprocessing, which combines biocatalytic molecular diversity and in vitro metabolic pathway engineering with high-throughput and high-content microfluidic- and microarray-based tools to generate biologically active compounds, and greatly expanded the fundamental understanding of enzymatic catalysis in abiotic environments critical for chemical and pharmaceutical processing. Finally, he has used biomolecular discovery and engineering to address clinical translation in areas of infectious disease, neurological diseases and anticoagulant therapy.

Primary Research Focus
Biocatalysis and Cell-Free Metabolic Engineering
Other Focus Areas

Biocatalysis and Cell-Free Metabolic Engineering, Biomanufacturing, 3D Cell Culture Engineering and Organoid Development, Immunoengineering, Biomolecular Discovery

Research Groups

Teaching

Office Hours

By appointment.

Current Courses

Introduction to Biochemical Engineering (CHME4430 and CHME 6430).

Recognition

Professor Dordick has received numerous awards. He was elected to the National Academy of Engineering in 2021. He has been awarded the James Bailey Award from the Society for Biological Engineering (AIChE), the Amgen Award in Biochemical and Molecular Engineering, Food, Pharmaceutical and Bioengineering Award of the American Institute of Chemical Engineers, Marvin J. Johnson Award and the Elmer Gaden Award both of the American Chemical Society, the International Enzyme Engineering Award, and an NSF Presidential Young Investigator Award. He has cofounded several companies, including EnzyMed (now part of Albany Molecular Research, Inc.), Solidus Biosciences, Inc., and Redpin Therapeutics. He has also served on multiple White House-sponsored panels and committees in biomanufacturing. Dr. Dordick has published over 400 papers and is an inventor/co-inventor on nearly 50 patents and patent applications.

Awards & Honors

Honors, Awards, and Lectureships

2022    James E. Bailey Award, Society for Biological Engineering, American Institute of Chemical Engineers

2021    Elected to the National Academy of Engineering

2019    Amgen Biochemical and Molecular Engineering Award

2019    Rensselaer School of Engineering Outstanding Professor Award

2016    Robert Pigford Memorial Lecture, University of Delaware

2015    Food, Pharmaceutical and Bioengineering Award, American Institute of Chemical Engineers

2014    Elected to the National Academy of Inventors

2011    Inaugural Mylan Lecture, University of West Virginia

2011    Merck Lecture, University of Virginia

2010    Elected Fellow, American Chemical Society

2009    Outstanding Scientific Achievement Award, Defense Threat Reduction Agency

2007    Marvin J. Johnson Award, American Chemical Society Division of Biochemical

Technology

2007    Elmer Gaden Award, John Wiley & Sons and American Chemical Society Division of Biochemical           Technology

2007    Trustees Lecture, Rensselaer Polytechnic Institute

2007    School of Engineering Research Award, Rensselaer Polytechnic Institute

2004    Elected Fellow, American Association for the Advancement of Science

2003    International Enzyme Engineering Award

2003    School of Engineering Research Award, Rensselaer Polytechnic Institute

2000    Alan Berman Research Publications Award, U.S. Department of Defense

  1.    Howard P. Isermann Professorship, Department of Chemical Engineering, Rensselae Polytechnic Institute

1998    American Chemical Society Iowa Section Award

1998    Who’s Who in America

1997    Trapp Lecture in Biotechnology, Departments of Chemistry and Food Science and Engineering, Iowa State University

1996    Elected Fellow, American Institute of Medical and Biological Engineers

1996    Who’s who in Science and Engineering

1993    Leo Rettger Society Lecturer, American Society of Microbiology, Connecticut      Chapter

1992    Chairman, Division of Biochemical Technology, American Chemical Society

1991    Observer for National Academy of Sciences for IUPAC Meeting in Hamburg

1991    U.S. Delegate for U.S. - Korea Joint Seminar on Bioprocess Technology, Seoul

1989    Presidential Young Investigator Award, National Science Foundation

1989    Faculty Scholars Award, University of Iowa

1989    NASA Technical Innovation Brief

1988    Old Gold Summer Faculty Fellowship, University of Iowa

1983    Interox Predoctoral Fellowship, MIT

Presentations & Appearances

Plenary and Keynote Addresses

2016    Plenary Address for Korean Society of Biotechnology and Bioengineering, Gyeong-Ju, Korea

2014    Plenary Address for DECHEMA Annual Meeting, Aachen, Germany

2012    Keynote Opening Lecture, Biocat2012, Hamburg, Germany

2011    Plenary Address for the BioTrans Meeting, Giardina Naxos, Sicily, Italy

2010    Plenary Address for the AIChE National Meeting, Division 22, Salt Lake City, UT

2007    Keynote Address for the 12th Mexican Biotechnology and Bioengineering Conference, Morelia, Mexico

2006    Plenary Address for the Eastern Mediterranean Chemical Engineering Conference, Dead Sea, Israel

2005    Plenary Address for Enzyme Engineering XVIII, Geong-Ju, Korea

2005    Plenary Address for Biochemical Engineering XIV, Harrison Hot Springs, BC

2004    Plenary Address for the American Institute of Chemical Engineers, Austin, TX

2001    Plenary Address for the 6th Biochemical Engineering Conference, Taipei, Taiwan

1998    Plenary Address for Division 15 for the American Institute of Chemical Engineers, Miami, FL

1996    Plenary Address for the Division of Polymer and Materials Science and Engineering, ACS, New Orleans, LA

1995    Keynote Address for the Colorcon Symposium on Controlled Release, Princeton, NJ

1995    Keynote Address for the Carbohydrate Bioengineering Meeting, Helsingor, Denmark

1994    Plenary Address for the 4th International Workshop on Oligo- and Polysaccharides, Aussois, France

1994    Plenary Address for the Biodegradable Polymers Symposium, Boston, MA.

1993    Plenary Address for the International Congress on Chemicals from Biotechnology, Hannover, Germany.

1993    Plenary Address for the European Symposium on Biocatalysis, Graz, Austria.

Publications

Recent Publications:

400.     P.S. Kwon, H. Oh, S.J. Kwon, W. Jin, F. Zhang, K. Fraser, J.J. Hong, R.J. Linhardt, and J.S. Dordick (2020), “Sulfated Polysaccharides Effectively Inhibit SARS-CoV-2 in Vitro”, Cell Discovery, 6, 50.

401.     L. Yan, P. Brodfuehrer, L. Fu, F. Zhang, S. Chen, J.S. Dordick, and R.J. Linhardt (2020), “Chemical O-Sulfonation of N-sulfoheparosan: A Route to Rare N-sulfo-3-O-Sulfoglucosamine and 2-O-sulfoglucuronic acid”, Glycoconj. J. 37, 589-597.

402.     R. Muckom, X. Bao, E. Tran, E. Chen, A. Murugappan, J.S. Dordick, D.S. Clark, and D.V. Schaffer (2020), “High-Throughput 3D Screening for Differentiation of hPSC-Derived Cell Therapy Candidates”, Sci. Adv. 6, eaaz1457.

403.     S. Bhattacharya, D. Kim, S. Gopal, A. Tice, K. Lang, J.S. Dordick, J. L. Plawsky, and R.J. Linhardt (2020), “Antimicrobial Effects of Positively Charged, Conductive Electrospun Polymer Fibers”, Mater. Sci. Eng. C Mater. Biol. Appl. 116, 111247.

404.     S.J. Kwon, D. Lee, S. Gopal, A. Ku, H. Moon, and J.S. Dordick (2020), “Three-Dimensional in Vitro Devices Using Patient-Derived Cells for HighThroughput Screening of Drug Combinations”, Med. Dev. Sensors 3, e10067.

405.     C.S. Morrison, E.E. Paskaleva, M.A. Rios, T.P. Beusse, E.M. Blair, L.Q. Lin, J.R. Hu, A.H. Gorby, D.R. Dodds, W.B. Armiger, J.S. Dordick, and M.A.G. Koffas (2020), “Improved Soluble Expression and Use of Recombinant Human Renalase”, 15, PLoS One, e0242109.

406.     L. Yan, L. Fu, K. Xia, S. Chen, F. Zhang, J.S. Dordick, and R.J. Linhardt (2020), “A Revised Structure for the Glycolipid Terminus of Escherichia coli K5 Heparosan Capsular Polysaccharide”, Biomolecules 10, 1516.

407.     P. Datta, L. Yan, A. Awofiranye, J.S. Dordick, and R.J. Linhardt (2020), “Heparosan Chain Characterization: Sequential Depolymerization of E. Coli K5 Heparosan by a Bacterial Eliminase Heparin Lyase III and a Bacterial Hydrolase Heparanase Bp to Prepare Defined Oligomers”, Biotechnol. J. 16, e2000336.

408.     A. Bhagwat, M. Mixon, C.H. Collins, and J.S. Dordick (2020), “Opportunities for Broadening the Application of Cell Wall Lytic Enzymes”, Appl. Microbiol. Biotechnol. 104, 9019-9040.

409.     P. Datta, L. Fu, P. Brodfuerer, J.S. Dordick, and R.J. Linhardt (2021), “High Density Fermentation of Probiotic E. coli Nissle 1917 Towards Heparosan Production, Characterization, and Modification”, Appl. Microbiol. Biotechnol. 105, 1051-1062.

410.     J. Zha, Z. Liu, R. Sun, G. Gong, J.S. Dordick, and X. Wu (2021), “An Endolysin-Based Autolytic E. coli System for Facile Recovery of Recombinant Proteins,” J. Agric. Food Chem. 69, 3134-3143.

411.     A. Badri, A. Williams, A. Awofiranye, P. Datta, K. Xia, H. We, K. Fraser, J.S. Dordick, R.J. Linhardt, and M.A.G. Koffas (2021), “Complete Biosynthesis of a Sulfated Chondroitin in Escherichia coli,” Nat. Commun. 12, 1389.

412.     S.N. Baytas, S.S. Varghese, W. Jin, Y. Yu, P. He, M. Douaisi, F. Zhang, P. Brodfuehrer, K. Xia, J.S. Dordick, and R.J. Linhardt (2021), “Preparation of Low Molecular Weight Heparin from a Remodeled Bovine Intestinal Heparin”, J. Med. Chem. 64, 2242-2253.

413.     A. Bhagwat, F. Zhang, C.H. Collins, and J.S. Dordick (2021), “Influence of Bacterial Culture Medium on Peptidoglycan Binding of Cell Wall Lytic Enzymes,” J. Biotechnol. 330, 27-34.

414.     L.S. Wang, S. Xu, S. Gopal, E. Kim, D. Kim, M. Brier, K. Solanki, and J.S. Dordick (2021), “Facile Fabrication of Antibacterial and Antiviral Perhydrolase-Polydopamine Composite Coatings,” Sci. Rep. 11, 12410.

415.     S. Gopal, A.E. Osborne, L. Hock, J. Zemianek, K. Fang, G. Gee, R. Ghosh, D. McNally, S.M. Cramer, and J.S. Dordick (2021), “Advancing a Rapid, High Throughput Screening Platform for Optimization of Lentivirus Production”, Biotechnol. J. 16, e2000621.

416.     S. Gopal, S.J. Kwon, B. Ku, D.W. Lee, J. Kim, and J.S. Dordick (2021), “3D Tumor Spheroid Microarray for High-Throughput, High-Content Natural Killer Cell-Mediated Cytotoxicity”, Commun. Biol. 4, 893.

417.     P. Datta, F. Zhang, J.S. Dordick, and R.J. Linhardt (2021), “Platelet Factor 4 Polyanion Immune Complexes: Heparin Induced Thrombocytopenia and Vaccine-Induced Immune Thrombotic Thrombocytopenia,” Thromb. J. 19, 66.

418.     Y. Song, P. He, A.L. Rodrigues, P. Datta, R. Tandon, J.T. Bates, M.A. Bierdeman, C; Chen, J.S. Dordick, F. Zhang, and R.J. Linhardt (2021), “Anti-SARS-CoV-2 Activity of Rhamnan Sulfate from Monostroma nitidu,” Marine Drugs 19, 685.

419.     I. Lee, S.J. Kwon, M. Sorci, P.S. Heeger, and J.S. Dordick (2021), “Highly Sensitive Immuno-CRISPR Assay for CXCL9 Detection,” Anal. Chem. 93, 16528-16534.

420.     F. Zhang, P. He, A.L. Rodrigues, W. Jeske, R. Tandon, J.T. Bates, M.A. Bierdeman, J. Fareed, J.S. Dordick, and R.J. Linhardt (2022), “Potential Anti-SARS-CoV-2 Activity of Pentosan Polysulfate and Mucopolysaccharide Polysulfate,” Pharmaceuticals, 15, 258.

421.     S. Talekar, B.H. Jo, J.S. Dordick, and J. Kim (2022), “Carbonic Anhydrase for CO2 Capture, Conversion and Utilization,” Curr. Opin. Biotechnol., 74, 230-240.

422.     J.S. Dordick and J. Kim (2022), “Editorial Overview: Emerging Routes to Sustainable Energy Capture and Conversion into Value-Added Products,” Curr. Opin. Biotechnol., 73, iii-vi.

423.     A.L. Gelbach, F. Zhang, S.J. Kwon, J.T. Bates, A.P. Farmer, J.S. Dordick, C. Wang, and R.J. Linhardt (2022), “Interactions Between Heparin and SARS-CoV-2 Spike Glycoprotein RBD from Mmicron and Oher Variants.” Front. Mol. Biosci. 9,  912887.

424.     R. Ghosh, S. Koley, S. Gopal, A.L. Rodrigues, J.S. Dordick, and S.M. Cramer (2022), “Evaluation of Lentiviral Vector Stability and Development of Ion Exchange Purification Processes.” Biotechnol. Prog. (Online ahead of print).

425.     V. Narayanan, A.L. Rodrigues, and J.S. Dordick (2022), “Influence of Circadian Rhythm on Drug Metabolism in 3D Hepatic Spheroids.” Biotechnol. Bioeng. (Online ahead of print).

The following is a selection of recent publications in Scopus. Jonathan Dordick has 456 indexed publications in the subjects of Biochemistry, Genetics and Molecular Biology, Chemical Engineering, and Chemistry.

Ronit Ghosh, Sushmita Koley, Sneha Gopal, Andre L. Rodrigues, Jonathan S. Dordick, Steven M. Cramer
Biotechnology Progress
, 2022
.
Yanlei Yu, Li Fu, Peng He, Ke Xia, Sony Varghese, Jonathan Dordick, Hong Wang, Fuming Zhang, Robert J. Linhardt
Carbohydrate Polymers
, 295
, 2022
.
Norma A. Alcantar, Scott Banta, Anthony D. Cak, Xi Chen, Christopher DelRe, Leila F. Deravi, Jonathan S. Dordick, Brian M. Giebel, Dianne Greenfield, Peter M. Groffman, Mandë Holford, George John, Neel S. Joshi, Nick A. Kotov, Jin Kim Montclare, Bradley S. Moore, Julia H. Ortony, Andrew B. Reinmann, Jiye Son, Ruth E. Stark, Rein V. Ulijn, Charles J. Vörösmarty, Corey J. Wilson
Matter
, 5
, 2022
, pp.1980-1984
.
Sachin Talekar, Byung Hoon Jo, Jonathan S. Dordick, Jungbae Kim
Current Opinion in Biotechnology
, 74
, 2022
, pp.230-240
.
Yanlei Yu, Li Fu, Peng He, Ke Xia, Sony Varghese, Hong Wang, Fuming Zhang, Jonathan Dordick, Robert J. Linhardt
ACS Chemical Biology
, 17
, 2022
, pp.637-646
.
Fuming Zhang, Peng He, Andre L. Rodrigues, Walter Jeske, Ritesh Tandon, John T. Bates, Michael A. Bierdeman, Jawed Fareed, Jonathan Dordick, Robert J. Linhardt
Pharmaceuticals
, 15
, 2022
.
Jonathan S. Dordick, Jungbae Kim
Current Opinion in Biotechnology
, 73
, 2022
, pp.iii-vi
.
Vibha Narayanan, Andre L. Rodrigues, Jonathan S. Dordick
Biotechnology and Bioengineering
, 2022
.
Adrianne L. Gelbach, Fuming Zhang, Seok Joon Kwon, John T. Bates, Andrew P. Farmer, Jonathan S. Dordick, Chunyu Wang, Robert J. Linhardt
Frontiers in Molecular Biosciences
, 9
, 2022
.
Inseon Lee, Seok Joon Kwon, Mirco Sorci, Peter S. Heeger, Jonathan S. Dordick
Analytical Chemistry
, 93
, 2021
, pp.16528-16534
.

View All Scopus Publications

The Dordick Research Lab

The Dordick Group includes chemical engineers, bioengineers, biologists, and chemists all focused on gaining a quantitative understanding of biological principles and applying them to advance biomanufacturing, engineering of the natural and synthetic immune system, neurotechnologies, and drug discovery. Specific areas of current research include Biocatalysis and Biomanufacturing, Biomolecular Engineering of Antibacterial and Antiviral Agents, Cellular Engineering, Neuromodulation, and AI/Machine Learning for Drug Discovery.

https://enzymes.che.rpi.edu/

Group picture of the Dordick research group outside
 Summer 2021 Group Retreat
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