Keith Fraser

Lecturer, Biological Sciences

Dr. Fraser's research interests are broadly in the area of computational biology and how in silico models can be developed to advance our understanding of a range of biochemical mechanisms. These include protein folding, protein ligand interactions and drug toxicity.

Education

Ph.D. Biology, (Rensselaer Polytechnic Institute), M.S. Biology, (St. John's University), B.S. Biology (St. John's University)

Research Focus
  • Biochemistry
  • Biophysics
  • Computational Biology
Contact Information
Select Works
  • Ren, S; Fraser, K; Kuo, L; Chauhan, N; Adrian, AT; Zhang, F; Linhardt, RJ; Kwon, PS; Wang, X. Designer DNA nanostructures for viral inhibition. Nature Protocols (2022)
  • Badri, A; Williams, A; Awofiranye, A; Datta, P; Xia, K; He, W; Fraser, K; Dordick, JS; Linhardt, RJ; Koffas, MAG. Complete biosynthesis of a sulfated chondroitin in Escherichia coli. Nature Communications 12, 1389 (2021)
  • Kwon, PS; Oh, H; Kwon, SJ; Jin, W; Zhang, F; Fraser, K; Hong, JJ; Linhardt, RJ; Dordick, JS. Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro. Cell Discovery, 6, 50 (2020)
  • Kwon, PS; Ren, S; Kwon, SJ, Kizer, M; Kuo, L; Zhou, F; Zhang, F; Kim, D; Fraser, K; Kramer, LD; Seeman, NC; Dordick, JS; Linhardt, RJ; Chao, J; Wang, X. Designer DNA architecture offers precise and multivalent spatial pattern recognition for viral sensing and inhibition. Nature Chemistry, 12, 26-35 (2020)
  • Kim, D; Kwon, SJ; Sauve, J; Fraser, K; Kemp, L; Lee, I; Nam, J; Kim, J; Dordick, JS. Modular Assembly of Unique Chimeric Lytic Enzymes on a Protein Scaffold Possessing Anti-Staphylococcal Activity. Biomacromolecules, 2019, 20, 10, 4035-4043
  • Kizer, M; Huntress, ID; Walcott, BD; Fraser, K; Bystroff, C.; Wang, X. The complex between a multi-crossover DNA nanostructure, PX-DNA, and T7 endonuclease I. Biochemistry, 2019, 58, 10, 1332-1342
  • Wu, X; Fraser, K; Zha, J; Dordick, JS. Flexible Peptide Linkers Enhance the Antimicrobial Activity of Surface Immobilized Bacteriolytic Enzymes. ACS Appl. Mater. Interfaces, 2018, 10 (43), pp 36746-36756
  • Fraser, K; Bruckner, D.M; Dordick, JS. Advancing Predictive Hepatotoxicity at the Intersection of Experimental in Silico, and Artificial Intelligence Technologies. Chem. Res. Toxicol., 2018, 31 (6), pp 412-430