Leo Q. Wan

Associate Professor, Biomedical Engineering

Leo received both B.S. and M. Eng. degrees in Mechanical Engineering from the University of Science and Technology of China (USTC), and a PhD in Biomedical Engineering from Columbia University, where he became a post-doc on stem cells and tissue engineering. He joined the Biomedical Engineering Department at the Rensselaer Polytechnic Institute as an assistant professor in 2011, and became an associate professor in 2016.

Leo's research is focused on developing novel strategies for tissue regeneration/repair, and establishing innovative organ-on-a-chip devices for disease diagnosis and drug screening. His lab unitizes interdisciplinary approaches including micro-/nanofabrication, stem cells, tissue engineering, biomaterial, cell/tissue biomechanics, and bioimaging.

Leo is a Pew scholar (Class 2013), and recipient of NIH Director's New Innovator Award, National Science Foundation Early Career Award, American Heart Association Scientist Development Grant, and the March of Dimes Basil O’Connor Starter Scholar Research Award.


Ph.D. in Biomedical Engineering, Columbia University 2007

M.Eng. in Fluid Mechanics, University of Science and Technology of China (USTC) 2001

B.S. in Theoretical and Applied Mechanics, University of Science and Technology of China (USTC) 1998

Select Works
  • P Ray, AS Chin, KE Worley, J Fan, G Kuar, M Wu, and LQ Wan*, 2018. Intrinsic Cell Chirality Regulate Left-Right Symmetry Breaking During Cardiac Looping, Proceedings of National Academy of Sciences, pii: 201808052. https://doi.org/10.1073/pnas.1808052115.
  • AS Chin, KE Worley, P Ray, G Kuar, J Fan, and LQ Wan*, 2018. Cell Chirality Revealed By Three-Dimensional Spontaneous Rotation, Proceedings of National Academy of Sciences, 115(18), pp.12188-12193, https://doi.org/10.1073/pnas.1805932115.
  • A Abu-Hakmeh, AKM Fleck, and LQ Wan*, 2018. Temporal Effects of Cytokine Treatment on Lubricant Synthesis and MMP Activity of Fibroblast-like Synoviocytes, Journal of Tissue Engineering and Regenerative Medicine, epub ahead of print. https://doi.org/10.1002/term.2771.
  • KE Worley, AS Chin, and LQ Wan*, 2018. Lineage-Specific Chiral Biases of Human Embryonic Stem Cells During Differentiation, Stem Cell International, Vol. 2018, 1848605. https://doi.org/10.1155/2018/1848605.
  • J. Fan, P Ray, Y Lu, G Kaur, JJ Schwarz, and LQ Wan*, 2018. Cell chirality regulates intercellular junctions and endothelial permeability. Science Advances, 4, eaat2111.https://doi.org/ 10.1126/sciadv.aat2111.
  • KE Worley, J Rico-Varela, D Ho and LQ Wan*, 2018. Teratogen Screening with Human Pluripotent Stem cells. Integrative Biology, 10(9), pp491-501.
  • J Rico-Varela, D Ho and LQ Wan*, 2018. In vitro Microscale Systems for Embryogenesis. Advanced Biosystems, 2 (6), 1700235.
  • EY Sun, AKM Fleck, A Abu-Hakmeh, A Kotsakis, GR Leonard, and LQ Wan*, 2018. Cartilage Metabolism and Mechanics Modulated By Synovial Fluid Through Metalloproteinase Proteins, Annals of Biomedical Engineering, 46(6), pp810-818.