Mattheos Koffas

Dorothy and Fred Chau ʼ71 Career Development Constellation Professor in Biocatalysis and Metabolic Engineering


Professor Mattheos Koffas, Ph.D., received his B.S. degree in Chemical Engineering from the National Technical University in Athens, Greece in 1994. He then joined the graduate program of the Department of Chemical Engineering at MIT where he worked on improving amino acid biosynthesis from Corynebacterium glutamicum. After completing his Ph.D. in 2000, he joined DuPont’s Central Research and Development as a research scientist where he worked on engineering the carotenoid biosynthesis of an obligate methanotroph. In August of 2002 he joined the faculty of the Department of Chemical and Biological Engineering at SUNY Buffalo as a tenure-track Assistant Professor and was promoted to Associate Professor with tenure in the summer of 2008. In January of 2011 Prof. Koffas moved to his current position at Rensselaer. He was appointed Dorothy and Fred Chau '71 Career Development Constellation Professor in Biocatalysis and Metabolic Engineering in 2015.  In his research career, Dr. Koffas has worked with a variety of microorganisms and natural products including amino acids, polyphenols, fatty acids and terpenoids. He has published more than 150 peer-reviewed publications, more than 12 book chapters and holds 10 patents. He is a member of the editorials boards of various journals in the area of bioengineering, Editor in Chief of Metabolic Engineering Communications and Associate Editor for Biotechnology Advances. His research has been funded by federal agencies (NIH, ARPA-E and NSF), the state of New York (NYStem), and industrial partners (Evonik, Firstwave Technologies and Chromadex).

Other affililations: Chemical and Biological Engineering, Biological Sciences


Other Focus Areas

Metabolic Engineering, Industrial Microbiology, Synthetic Biology, Natural Products


The following is a selection of recent publications in Scopus. Mattheos Koffas has 220 indexed publications in the subjects of Biochemistry, Genetics and Molecular Biology, Medicine, Immunology and Microbiology.

Nicholas A. Kaplan, Khondokar Nowshin Islam, Fiona C. Kanis, Jack R. Verderber, Xin Wang, J. Andrew Jones, Mattheos A.G. Koffas
Applied and Environmental Microbiology
, 90
, 2024
W. Liu, H. Li, J. X. Zhang, Y. N. Xu, X. M. Zhang, J. S. Shi, M. A.G. Koffas, Z. H. Xu
Systems Microbiology and Biomanufacturing
, 4
, 2024
, pp.127-137
Guoqiang Xu, Jiyue Wang, Jiancheng Shen, Yaxin Zhu, Wanjing Liu, Yuhang Chen, Jian Zha, Xiaomei Zhang, Xiaojuan Zhang, Jinsong Shi, Mattheos A.G. Koffas, Zhenghong Xu
Metabolic Engineering
, 81
, 2024
, pp.238-248
Wei Liu, Hui Li, Dongxin Guo, Yu Ni, Xiaomei Zhang, Jinsong Shi, Mattheos A.G. Koffas, Zhenghong Xu
Journal of Steroid Biochemistry and Molecular Biology
, 238
, 2024
Xin Yi Zan, Yun Ting Xu, Jing Jing Guo, Lei Sun, Hao Ran Cao, Jing Ting Zhang, Xi Cao, Feng Jie Cui, Wen Jing Sun, Shu Hao Huo, Yuan Da Song, Mattheos A.G. Koffas
Process Biochemistry
, 137
, 2024
, pp.164-174
Alexander Connor, R. Helen Zha, Mattheos Koffas
Microbial Cell Factories
, 23
, 2024
Alexander Connor, Caleb Wigham, Yang Bai, Manish Rai, Sebastian Nassif, Mattheos Koffas, R. Helen Zha
Metabolic Engineering Communications
, 16
, 2023
Nisit Watthanasakphuban, Luan Van Nguyen, Yu Shen Cheng, Pau Loke Show, Malinee Sriariyanun, Mattheos Koffas, Kittipong Rattanaporn
, 9
, 2023
Jian Zha, Zhen Zhao, Zhengyang Xiao, Thomas Eng, Aindrila Mukhopadhyay, Mattheos AG Koffas, Yinjie J. Tang
Current Opinion in Biotechnology
, 79
, 2023
Philippe Jeandet, Md Sahab Uddin, Christophe Clément, Aziz Aziz, Cédric Jacquard, Haroon Khan, Muhammad Ajmal Shah, Essaid Ait Barka, Mattheos Koffas, Seyed Mohammad Nabavi, Eduardo Sobarzo-Sánchez, Jean Hugues Renault
Natural Product Reports
, 40
, 2023
, pp.1045-1057

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